N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation
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منابع مشابه
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
In differentiated 3T3-F442A adipocytes, insulin stimulated rapid and transient phosphorylation of c-Jun. Insulin also stimulated phosphorylation of c-Fos and several Fos-related proteins (pp72, pp45, and pp39) as indicated by precipitation with anti-c-Fos antibody following exposure to denaturating conditions. Phosphorylation of c-Fos was stimulated by 7-fold by 60 min, while phosphorylation of...
متن کاملc-Fos phosphorylation induced by H2O2 prevents proteasomal degradation of c-Fos in cardiomyocytes.
Oxidants cause activation of the AP-1 transcription factor in cardiomyocytes. c-Fos, a component of the AP-1 transcription factor, is transiently induced by H2O2 and the induction is sensitive to the protein synthesis inhibitor cycloheximide. With high percentage gel electrophoresis, multiple c-Fos bands were resolved by Western blot analyses, indicating post-translational modification of newly...
متن کاملc-fos and c-myc gene activation, ionic signals, and DNA synthesis in thymocytes.
Among the earliest responses to mitogens that have been detected in normal quiescent cells are ionic changes: we have described rapid increases in the cytosolic free Ca2+ concentration ([Ca]i) and in the intracellular pH (pHi) in mitogen-stimulated thymocytes and fibroblasts (Hesketh, T. R., Moore, J. P., Morris, J. D. H., Taylor, M. V., Rogers, J., Smith, G. A., and Metcalfe, J. C. (1985) Natu...
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Background: Hepatocellular carcinoma is the most common primary malignant tumor of the liver. The effect of some genes especially those involved in cell cycle regulation have been shown in the development of this cancer in several studies but there are some controversies about them yet. Materials and methods: The paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hep...
متن کاملTyrosine phosphorylation regulates phospholipase C activation in human T-cells.
Introduction One early transmembrane signal in response to stimulation of the T-cell antigen receptor (CD 3/Ti) is the activation of phosphatidylinositol (Ptd1ns)specific phospholipase C (PLC). The resulting formation of inositol 1,4,5-trisphosphate (Ins( 1,4,5)q?) and diacylglycerol (DAG) causes calcium release from internal stores, calcium influx through calcium channels, and translocation of...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2006
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1210137